The primary use for procaine is as an anaesthetic. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. check more Procaine hydrochloride price, Home | 33(12): p. 1573-9. Incompatible with strong oxidizing agents. and C. Stark-Adamec, The effects of procaine HCl on population cellular and evoked response activity within the limbic system of the cat. About one in 3000 white North Americans is homozygous (i.e. Procaine was first synthesized in 1905,[4] shortly after amylocaine. Molecular Weight 272.77 . Weight, Procaine impairs the function of 5-HT3 receptor-ion channel complex in rat sensory ganglion neurons. However, certain populations in the world such as the Vysya community in India commonly have a deficiency of this enzyme. Procaine is a local anesthetic drug of the amino ester group. Shanghai Jizhi Biochemical Technology Co., Ltd, Magnesium aspartate,mixted with procaine hydrochloride, Benzenecarboximidamide hydrochloride (1:1), (2S)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]-3-(4-methylpiperazin-1-yl)sulfonylpropanamide,hydrochloride. Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. [13], "Allocaine" redirects here. Nervousness and dizziness can arise from the excitation of the central nervous system, which may lead to respiratory failure if overdosed. Our editors will review what you’ve submitted and determine whether to revise the article. Novocain, procaine hydrochloride, is benzoic acid, 4-amino-, 2-(diethylamino) ethyl ester, monohydrochloride, the ester of diethylaminoethanol and aminobenzoic acid, with the following structural formula: It is a white crystalline, odorless powder that is freely soluble in water, but less soluble in alcohol. Service | Procaine also has growth-inhibitory effects in these cancer cells, causing mitotic arrest [2]. Vasoconstriction helps to reduce bleeding, increases the duration and quality of anesthesia, prevents the drug from reaching systemic circulation in large amounts, and overall reduces the amount of anesthetic required. Dentists, however, found it very useful.[7]. Stable. [2]. Cancer Res, 2003. 11(4): p. 345-64. Product Classification | Weight, Procaine impairs the function of 5-HT3 receptor-ion channel complex in rat sensory ganglion neurons. [5] It was created by the chemist Alfred Einhorn who gave the chemical the trade name Novocaine, from the Latin nov- (meaning "new") and -caine, a common ending for alkaloids used as anesthetics. Procaine hydrochloride, also called Novocain, or Novocaine, synthetic organic compound used in medicine as a local anesthetic.Introduced in 1905 under the trade name Novocaine, it became the first and best-known substitute for cocaine in local anesthesia. Description: Procaine Hydrochloride is a local anesthetic drug of the amino ester group.Target: OthersProcaine is a local anesthetic of the ester type that has a slow onset and a short duration of action.Procaine (0.01-100 microM) inhibited the 5-HT3 receptor-mediated inward current in the whole-cell patch clamp recording. Generally used in a 1 to 10 percent saline solution, procaine hydrochloride is administered by injection for infiltration (area flooding as in dental anesthesia), nerve-block, spinal, and caudal anesthesia. Beilstein/REAXYS Number 3917802 . Procaine can also demethylate densely hypermethylated CpG islands. 3(5) , 268-273, (2007). Villar-Garea, A., et al., Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. A 1% procaine injection has been recommended for the treatment of extravasation complications associated with venipuncture, steroids, and antibiotics. EXAMINE SOLU… Journals | It is not to be confused with, "Novocaine" redirects here. Prior to the discovery of amylocaine and procaine, cocaine was a commonly used local anesthetic. Allergic reactions to procaine are usually not in response to procaine itself, but to its metabolite PABA. 33(12): p. 1573-9. It was introduced into medical use by surgeon Heinrich Braun. [8] As a dental anesthesic, for example, more novocaine is needed for root canal treatment than for a simple filling. Procaine hydrochloride, also called Novocain, or Novocaine, synthetic organic compound used in medicine as a local anesthetic. The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc... Levamisole, an anthelmintic drug, has been increasingly employed as an adulterant of illicit street cocaine over the last decade; recently, the use of tetramisole, the racemic mixture of levamisole an... Electrolysis is omnipresent in all electrochemical processes including electromembrane extraction (EME). Procaine is an occasional additive in illicit street drugs, such as cocaine. By signing up for this email, you are agreeing to news, offers, and information from Encyclopaedia Britannica. Adamec, R.E. 63(16): p. 4984-9. Introduced in 1905 under the trade name Novocaine, it became the first and best-known substitute for cocaine in local anesthesia. Procaine appears to produce a competitive inhibition on 5-HT3 receptors with a KD of 1.7 microM [1]. Procaine hydrochloride 5 Product Results | Match Criteria: Product Name, Property, Description View information & documentation regarding Procaine hydrochloride, including CAS, MSDS & more. About Us | Adamec, R.E. [6] Einhorn wished his new discovery to be used for amputations, but for this surgeons preferred general anesthesia. Corrections? 63(16): p. 4984-9. Chemical genetics reveals a complex functional ground state of neural stem cells. Each mL contains 100 mg procaine hydrochloride and 4 mg acetone sodium bisulfite as antioxidant. Prog Neuropsychopharmacol Biol Psychiatry, 1987. [11], Procaine can also cause allergic reactions causing individuals to have problems with breathing, rashes, and swelling. It is most commonly used in dental procedures to numb the area around a tooth and is also used to reduce the pain of intramuscular injection of penicillin. MSDS/SDS Database Search | For other uses, see, InChI=1S/C13H20N2O2/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H3, "How long does numbness last after the dentist? Selling Leads | HCl . Procaine Hydrochloride is a local anesthetic drug of the amino ester group.Target: OthersProcaine is a local anesthetic of the ester type that has a slow onset and a short duration of action.Procaine (0.01-100 microM) inhibited the 5-HT3 receptor-mediated inward current in the whole-cell patch clamp recording. It has likewise been recommended for treatment of inadvertent intra-arterial injections (10 ml of 1% procaine), as it helps relieve pain and vascular spasm. It acts mainly as a sodium channel blocker. 11(4): p. 345-64. Learn more about Procaine uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Procaine The depression causes the nervous system to become hypersensitive, producing restlessness and shaking, leading to minor to severe convulsions. Quantitative aspects of electrolysis in electromembrane extractions of acidic and basic analytes. Determination of levamisole and tetramisole in seized cocaine samples by enantioselective high-performance liquid chromatography and circular dichroism detection.

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